Elie Metchnikoff: father of natural immunity.
نویسنده
چکیده
We celebrate the centenary of the Nobel award to Elie Metchnikoff in 2008, shared with Paul Ehrlich, as respective pioneers of cellular and humoral immunology. Metchnikoff is rightly famous for his recognition of the biological significance of leukocyte recruitment and phagocytosis of microbes in host defence against infection, inflammation and immunity. As a comparative zoologist he utilised a broad range of model organisms for microscopic studies in vivo and in vitro. His work prefigures much of contemporary research in innate immunity. In this brief review, I cover some details of his Europe-wide life in Russia (mainly Odessa) and at the Pasteur Institute in Paris. He had a complex personality, yet his creative genius, imagination and insights justify the title of "Father of natural immunity".
منابع مشابه
Phagocytosis: The Legacy of Metchnikoff
This year is the centenary of the death of Elie Metchnikoff, the father of innate immunity. His work on phagocytosis has continued to flourish, particularly over the past half century.
متن کاملprobiotiCS in Surgery
It has been a century since Elie Metchnikoff, regarded as the father of probiotics, published the textbook “The Prolongation of Life: optimistic Studies” (1), describing the potential benefits of dietary supplementation with lactic acid bacteria. Ever since, a significant number of publications have been elaborated concerning the problem where analysis comprised the different varieties of bacte...
متن کاملThe Romantic Rationalist: a Study of Elie Metchnikoff.
TOWARDS the end of his life the tall, gaunt, stooping figure of Elie Metchnikoff (the French form of his name which he used for the last twenty-five years of his life) with long unkempt hair and flowing beard was almost a caricature of the Russian Bolshevik emigre'. He might have stepped from the pages ofa Dostoyevsky novel. His personality too seems to have combined the Rational and Romantic e...
متن کاملThe Origin of a Paradigm.
In this issue of the Journal of Innate Immunity , we are privileged to publish an article by Siamon Gordon [1] , Professor Emeritus of Cellular Pathology at the University of Oxford, commemorating the life and achievements of Elie Metchnikoff (1845–1916). Siamon Gordon is an outstanding scientist in the field of macrophage research and has made many important discoveries, e.g. the pattern recog...
متن کاملProbiotics: 100 years (1907-2007) after Elie Metchnikoff’s Observation
The scientific rationale for the use of live microbes in the prevention and treatment of infections came to lime-light most transparently at the beginning of the 20 century when Elie Metchnikoff in 1907 hypothesized that replacing or diminishing the number of ‘putrefactive’ bacteria in the gut with lactic acid bacteria could normalize bowel health and prolong life. After more than half a cent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- European journal of immunology
دوره 38 12 شماره
صفحات -
تاریخ انتشار 2008